Three dimeric analogues of bohemamines, dibohemamines D–F (1–3), together with dibohemamine A (4), were isolated from Streptomyces sp. CPCC 200497. Their structures were solved using a combination of mass spectrometry, 1D and 2D NMR spectroscopy, and CD. Dibohemamines D and E were new dimeric analogues of bohemamines, and dibohemamine F was a known compound obtained previously by semisynthesis. Dibohemamine F displayed potent cytotoxicity against cancer cell lines A549 and HepG2 with IC₅₀ values of 1.1 and 0.3 μM, respectively. Dibohemamines D and E showed moderate cytotoxicity against cancer cell lines A549 and HepG2.

中文翻译：

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链霉菌属物种的细胞毒性地波那敏D–F

bohemamines三个二聚体类似物，dibohemamines d-F（1 - 3）中，用dibohemamine A（一起4）中，从分离链霉菌属。CPCC200497。使用质谱，1D和2D NMR光谱以及CD的组合解析了它们的结构。地波西米胺D和E是波希米胺的新的二聚体类似物，而地波西米胺F是先前通过半合成获得的已知化合物。Dibohemamine F表现出对癌细胞系A549和HepG2的有效细胞毒性，IC ₅₀值分别为1.1和0.3μM。地波hemamines D和E对癌细胞系A549和HepG2表现出中等的细胞毒性。