Zanoni et al. (2017) show that the LPS receptor CD14 promotes internalization of oxidized phospholipids, a hallmark of dying cells, triggering hyperactivation of dendritic cells and macrophages. Their findings reveal CD14 as a regulator of responses to infection and damage, relaying context-dependent signals that determine inflammatory cell fate decisions.

中文翻译：

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CD14-老相识的新技巧

Zanoni等。（2017）表明LPS受体CD14促进了氧化磷脂的内在化，这是垂死细胞的标志，触发了树突状细胞和巨噬细胞的过度活化。他们的发现揭示了CD14可以作为对感染和损伤反应的调节剂，可以传递决定炎症细胞命运决定的上下文相关信号。