Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins. Amyloid formation can be negatively regulated, suggesting that it presents a regulatory point in multiple biological processes.

中文翻译：

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观点的RHIM：功能淀粉样蛋白的飞行

果蝇IMD途径识别细菌肽聚糖可触发NF-κB活化和相关的免疫反应。在本期《免疫》中，克莱诺（Kleino）等人。（2017）显示，IMD途径中的蛋白质通过类似于哺乳动物RIPK蛋白中的RHIM母题的隐性母题形成功能性淀粉样蛋白。淀粉样蛋白的形成可以被负调控，表明它在多个生物学过程中都表现出一个调控点。