Glucose uptake in muscle cells in response to insulin is a fundamental mechanism for metabolism. The inability of cells to mobilize the specific glucose transporter GLUT4 is believed to be at least partially accountable for diseases, like diabetes, where cells do not respond to an insulin stimulus. In this work, a microchip is used to detect electrochemically glucose uptake from C2C12 myoblasts cultured on a patch of paper upon exposure to insulin. More importantly, the data suggest a new role for dynamin, a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis. It is also shown in vivo that dynamin is involved in the response to glucose in a completely distinct organism, namely the nematode Caenorhabditis elegans. The new mechanism for dynamin could therefore be more generally relevant in vivo and may play a role in insulin resistance.

中文翻译：

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dynamin在调节葡萄糖摄取中的作用的多尺度研究

响应胰岛素，肌肉细胞中的葡萄糖摄取是新陈代谢的基本机制。人们认为细胞不能动员特定的葡萄糖转运蛋白GLUT4至少部分负责细胞对胰岛素刺激无反应的疾病，例如糖尿病。在这项工作中，微芯片用于检测暴露于胰岛素的纸片上培养的C2C12成肌细胞的电化学葡萄糖摄取。更重要的是，这些数据表明，动力分子具有新的作用，它是一种通过促进胞吐作用而参与GLUT4易位的分子运动。体内还显示，在完全不同的生物体即线虫秀丽隐杆线虫中，动力蛋白参与了对葡萄糖的反应。。因此，用于动力的新机制在体内可能更普遍，并且可能在胰岛素抵抗中发挥作用。