Guanylate-binding proteins (GBPs) confer protection against intracellular pathogens. In this issue of Cell Host & Microbe, Wandel et al. (2017) report that cytosolic Shigella becomes trapped within a GBP coat that prevents bacterial cell-to-cell spread. However, this defense mechanism is counteracted by the bacterial E3 ubiquitin ligase IpaH9.8.

中文翻译：

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志贺氏菌保持移动

鸟苷酸结合蛋白（GBP）赋予针对细胞内病原体的保护作用。在本期《细胞宿主与微生物》中，Wandel等人。（2017）报告说，胞质志贺氏菌被困在GBP外套中，以防止细菌在细胞间扩散。但是，这种防御机制被细菌E3泛素连接酶IpaH9.8抵消。