Helicobacter pylori type IV secretion system injects the oncoprotein CagA into epithelial cells to drive carcinogenesis. In this issue of Cell Host & Microbe, Tegtmeyer et al. (2017) show that a secreted bacterial protease disrupts apical-junctional complexes, paving the way for H. pylori to access the basolateral compartment and trigger pathogenesis.

中文翻译：

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幽门螺杆菌可通过分子切割获得上皮进入

幽门螺杆菌IV型分泌系统将癌蛋白CagA注射到上皮细胞中以驱动癌变。在本期《细胞宿主与微生物》中，Tegtmeyer等人。（2017）表明，一种分泌的细菌蛋白酶破坏了根尖-结复合物，为幽门螺杆菌进入基底外侧隔室并触发发病机制铺平了道路。