Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a candidate switch that regulates metastatic spread.

中文翻译：

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神经母细胞瘤转移：利用禽神经嵴。

神经母细胞瘤是一种起源于神经嵴的胚胎癌，在诊断时经常显示转移。在本期《癌细胞》中，Delloye-Bourgeois 及其同事证明神经母细胞瘤细胞系和源自患者的异种移植物在鸡胚胎中植入并采用转移程序。他们将 Sema3C 确定为调节转移扩散的候选开关。