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The Stromal Niche for Epithelial Stem Cells: A Template for Regeneration and a Brake on Malignancy.
Cancer Cell ( IF 50.3 ) Pub Date : 2017-10-09 , DOI: 10.1016/j.ccell.2017.08.007
Kelsey J Roberts 1 , Aaron M Kershner 2 , Philip A Beachy 3
Affiliation  

Stromal restraint of cancer growth and progression-emerging as a widespread phenomenon in epithelial cancers such as bladder, pancreas, colon, and prostate-appears rooted in stromal cell niche activity. During normal tissue repair, stromal niche signals, often Hedgehog-induced, promote epithelial stem cell differentiation as well as self-renewal, thus specifying a regenerating epithelial pattern. In the case of cancerous tissue, stromal cell-derived differentiation signals in particular may provide a brake on malignant growth. Understanding and therapeutic harnessing of the role of stroma in cancer restraint may hinge on our knowledge of the signaling programs elaborated by the stromal niche.

中文翻译:

上皮干细胞的基质生态位:再生模板和恶性肿瘤制动。

间质抑制癌症的生长和进展——在膀胱、胰腺、结肠和前列腺等上皮癌中作为一种普遍现象出现——其根源在于基质细胞的生态位活动。在正常组织修复过程中,通常由 Hedgehog 诱导的基质生态位信号促进上皮干细胞分化和自我更新,从而指定再生上皮模式。在癌组织的情况下,特别是基质细胞衍生的分化信号可能会阻止恶性生长。对基质在癌症抑制中的作用的理解和治疗利用可能取决于我们对基质生态位所阐述的信号程序的了解。
更新日期:2017-10-09
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