Background Colorectal cancers are the third most common cancers in women and men in the USA. While dietary and lifestyle factors such as Western diet, physical inactivity and obesity have been linked to an increased risk of this malignancy, the mechanisms for these associations are unclear. GI hormones, including ghrelin, are involved in energy balance by mediating appetite and metabolism; however, the association between ghrelin and colorectal cancer has not been studied. Methods We conducted a case–control study nested within the all-male Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish smokers (aged 50–69 years) to examine serum ghrelin concentration and colorectal cancer risk. Data from 284 colon and 239 rectal cancers and 523 controls (matched on age, date of blood draw and serum availability) were analysed. ORs and 95% CIs were calculated using multivariable (conditional) logistic regression. Results Overall, low-serum ghrelin was significantly associated with increased risk of colorectal cancer (Q1 vs Q4: OR:1.57, 95% CI 1.05 to 2.34). For individuals developing tumours within 10 years of blood draw, those in the lowest quartile of serum ghrelin concentrations were statistically significantly more likely to develop colorectal cancers than those with higher serum ghrelin concentrations (OR: 10.86, 95% CI 5.01 to 23.55). However, for individuals with tumours developing more than 20 years after blood draw, low-serum ghrelin concentrations were associated with a decreased risk of colorectal cancer relative to those with the highest serum ghrelin concentrations (OR: 0.26, 95% CI 0.11 to 0.64). Conclusion Low-serum ghrelin was associated with an increased colorectal cancer risk within 10 years of blood draw with a decreased risk for developing colorectal cancer more than 20 years after blood draw. These results suggest that ghrelin concentrations may vary across the carcinogenic process.

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ATBC 研究中血清生长素释放肽与结直肠腺癌的风险相关

背景 结直肠癌是美国女性和男性中第三大最常见的癌症。虽然西方饮食、缺乏身体活动和肥胖等饮食和生活方式因素与这种恶性肿瘤的风险增加有关，但这些关联的机制尚不清楚。包括生长素释放肽在内的 GI 激素通过调节食欲和新陈代谢参与能量平衡；然而，尚未研究生长素释放肽与结肠直肠癌之间的关联。方法 我们在针对芬兰吸烟者（50-69 岁）的全男性 α-生育酚、β-胡萝卜素癌症预防研究中进行了病例对照研究，以检查血清生长素释放肽浓度和结直肠癌风险。分析了来自 284 名结肠癌和 239 名直肠癌以及 523 名对照（年龄、抽血日期和血清可用性匹配）的数据。使用多变量（条件）逻辑回归计算 OR 和 95% CI。结果 总体而言，低血清生长素释放肽与结直肠癌风险增加显着相关（第一季度与第四季度：OR：1.57，95% CI 1.05 至 2.34）。对于在抽血后 10 年内发生肿瘤的个体，血清生长素释放肽浓度最低四分位数的个体比血清生长素释放肽浓度较高的个体更容易患结直肠癌（OR：10.86，95% CI 5.01 至 23.55）。然而，对于抽血后肿瘤发展超过 20 年的个体，与血清生长素释放肽浓度最高的个体相比，低血清生长素释放肽浓度与结直肠癌风险降低相关（OR：0.26，95% CI 0.11 至 0.64） . 结论 低血清生长素释放肽与抽血 10 年内结直肠癌风险增加有关，抽血后 20 年以上发生结直肠癌的风险降低。这些结果表明，在致癌过程中，ghrelin 浓度可能会有所不同。