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Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion
Annual Review of Cell and Developmental Biology ( IF 11.3 ) Pub Date : 2017-10-06 00:00:00
Un Seng Chio, Hyunju Cho, Shu-ou Shan

Proper localization of membrane proteins is essential for the function of biological membranes and for the establishment of organelle identity within a cell. Molecular machineries that mediate membrane protein biogenesis need to not only achieve a high degree of efficiency and accuracy, but also prevent off-pathway aggregation events that can be detrimental to cells. The posttranslational targeting of tail-anchored proteins (TAs) provides tractable model systems to probe these fundamental issues. Recent advances in understanding TA-targeting pathways reveal sophisticated molecular machineries that drive and regulate these processes. These findings also suggest how an interconnected network of targeting factors, cochaperones, and quality control machineries together ensures robust membrane protein biogenesis.

中文翻译:

尾锚膜蛋白靶向和插入的机制

膜蛋白的正确定位对于生物膜的功能和细胞内细胞器同一性的建立至关重要。介导膜蛋白生物发生的分子机制不仅需要实现高度的效率和准确性,而且还需要防止可能对细胞有害的路外聚集事件。尾锚蛋白(TAs)的翻译后靶向为研究这些基本问题提供了易于处理的模型系统。了解TA靶向途径的最新进展揭示了驱动和调节这些过程的复杂分子机制。这些发现还表明靶向因子,伴侣蛋白和质量控制机制的互连网络如何共同确保稳健的膜蛋白生物发生。
更新日期:2017-10-07
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