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Copper-Based Metal-Organic Framework Applied in the Development of an Electrochemical Biomimetic Sensor for Catechol Determination
Electroanalysis ( IF 3 ) Pub Date : 2017-10-06 , DOI: 10.1002/elan.201700509
Daniela Brondani 1 , Eduardo Zapp 1 , Renata da Silva Heying 2 , Bernardo de Souza 2 , Iolanda Cruz Vieira 2
Affiliation  

In this study, the synthesis and characterization of a Cu-based metal-organic framework (MOF) [Cu3(BTC)2(H2O)3]n (where BTC=benzene-1,3,5-tricarboxylate), known as HKUST-1, were performed. The Cu-MOF was applied in the modification of a carbon paste to obtain a biomimetic sensor for the electrochemical determination of catechol. Kinetic assays confirmed that the Cu-MOF acts as a catalyst for the oxidation of catechol and it can be considered as a catechol oxidase mimetic. Under optimized conditions, the calibration curve for catechol presented a linear range of 8.0×10−7 to 3.2×10−5 mol L−1, with detection limit of=1.0×10−7 mol L−1. The sensor demonstrated good intra-day repeatability and inter-electrode reproducibility (relative standard deviations of 3.8 % (n=10) and 4.3 % (n=6), respectively). In the selectivity study, an adequate peak-to-peak separation was observed for hydroquinone and uric acid in relation to catechol, demonstrating that this sensor has the potential for use in the simultaneous determination of these compounds. This sensor was successfully applied in the determination of catechol in water samples.

中文翻译:

铜基金属有机骨架在开发用于邻苯二酚测定的电化学仿生传感器中的应用

在这项研究中,铜基金属有机骨架 (MOF) [Cu3(BTC)2(H2O)3]n(其中 BTC=苯-1,3,5-三羧酸盐)的合成和表征,称为 HKUST -1,被执行。将Cu-MOF应用于碳糊的改性以获得用于电化学测定邻苯二酚的仿生传感器。动力学分析证实,Cu-MOF 可作为儿茶酚氧化的催化剂,可被视为儿茶酚氧化酶模拟物。在优化条件下,邻苯二酚的校准曲线呈现8.0×10-7至3.2×10-5 mol L-1的线性范围,检出限=1.0×10-7 mol L-1。该传感器表现出良好的日内重复性和电极间重复性(相对标准偏差分别为 3.8% (n=10) 和 4.3% (n=6))。在选择性研究中,观察到对苯二酚和尿酸与儿茶酚的充分峰间分离,表明该传感器具有同时测定这些化合物的潜力。该传感器成功应用于水样中儿茶酚的测定。
更新日期:2017-10-06
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