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Self-Assembly Behavior and Biocompatible Cross-Linking of Double Hydrophilic Linear-Brush Block Copolymers
Biomacromolecules ( IF 6.2 ) Pub Date : 2017-10-05 00:00:00 , DOI: 10.1021/acs.biomac.7b01094
Noah Al Nakeeb 1 , Jochen Willersinn 1 , Bernhard V. K. J. Schmidt 1
Affiliation  

The self-assembly of a novel double hydrophilic block copolymer (DHBC) architecture is presented. By combining linear biomacromolecule pullulan with biocompatible poly(oligo(ethylene glycol) methyl ether) methacrylate) (P(OEGMA))-brush blocks via copper(I) catalyzed azide alkyne cycloaddition, a novel DHBC linear-brush combination is obtained. Self-assembly in water was observed via optical microscopy and dynamic light scattering (DLS). Moreover, DLS investigations showed that self-assembly efficiency significantly relies on the degree of polymerization of the brush-block. Furthermore, the self-assembly of the formed particles was investigated with cryogenic scanning electron microscopy (cryo-SEM). To preserve the aggregates at lower concentrations, a biocompatible and FDA approved cross-linking agent, namely, sodium trimetaphosphate (STMP), was utilized for cross-linking. The reaction of STMP and pullulan was followed by 31P NMR, while the presence of the cross-linking agent within the particles could be detected via the combination cryo-SEM and energy dispersive X-ray spectroscopy.

中文翻译:

双亲水线性刷嵌段共聚物的自组装行为和生物相容性交联

提出了一种新型的双亲水嵌段共聚物(DHBC)结构的自组装。通过经由铜(I)催化的叠氮化物炔烃环加成反应,将线性生物大分子支链淀粉与生物相容性聚(低聚(乙二醇)甲基醚)甲基丙烯酸酯(P(OEGMA))-刷嵌段结合,获得了新颖的DHBC线性-刷组合。通过光学显微镜和动态光散射(DLS)观察到水中的自组装。此外,DLS研究表明,自组装效率显着依赖于刷块的聚合程度。此外,用低温扫描电子显微镜(cryo-SEM)研究了形成的颗粒的自组装。为了将聚集体保持在较低的浓度,使用了生物相容性并获得FDA批准的交联剂,即三偏磷酸钠(STMP),用于交联。随后,STMP和支链淀粉反应31 P NMR,而颗粒内交联剂的存在可通过低温SEM和能量色散X射线光谱的组合检测。
更新日期:2017-10-05
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