Intestinal organoids offer great promise for modeling intestinal diseases; however, harvesting intestinal tissue is invasive and directed hPSC differentiation protocols are laborious and costly. In this issue of Cell Stem Cell, Miura and Suzuki (2017) describe the direct conversion of somatic cells from both mice and humans into robust intestinal epithelial tissue.

中文翻译：

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通过该程序实现：直接实现对肠上皮的重新编程。

肠道类动物器官为模拟肠道疾病提供了广阔的前景。然而，收获肠组织是侵入性的，并且定向的hPSC分化方案费力且昂贵。Miura和Suzuki（2017）在本期《细胞干细胞》中描述了小鼠和人类的体细胞直接转化为健壮的肠上皮组织的过程。