Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of cardiovascular diseases—have considerable potential in oncology. The RAS plays a crucial role in cancer biology and affects tumor growth and dissemination directly and indirectly by remodeling the tumor microenvironment. We review clinical data on the benefit of RASi in primary and metastatic tumors and propose that, by activating immunostimulatory pathways, these inhibitors can enhance immunotherapy of cancer.

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靶向肾素-血管紧张素系统以改善癌症治疗：免疫疗法的意义

广泛用于治疗心血管疾病的肾素-血管紧张素系统（RAS）抑制剂（RASi）在肿瘤学上具有相当大的潜力。RAS在癌症生物学中起着至关重要的作用，并通过重塑肿瘤微环境直接或间接影响肿瘤的生长和扩散。我们回顾了有关RASi在原发性和转移性肿瘤中获益的临床数据，并提出通过激活免疫刺激途径，这些抑制剂可以增强癌症的免疫治疗。