In recent years, anticancer nanomedicines have mainly been developed for chemotherapy and combination therapy in which the main contributing anticancer drugs are delivered by deliberately designed nano drug delivery systems (nano-DDSs). Inorganic nanocarriers equipped with fluorescent tracers have become attractive tools to monitor the whole drug delivery and release processes. The fluorescence signal of tracers could be observed concomitantly with drug release, and thus, this strategy is of great benefit to evaluate the therapeutic effects of the nano-DDSs. This review provides a brief overview about three inorganic nanocarriers for drug delivery, including mesoporous silica, Fe₃O₄, and hydroxyapatite. We mainly discussed about their preparation processes, drug loading capacities, and the development of different fluorescent materials (fluorescent dyes, quantum dots, fluorescent macromolecules, and rare earth metals) hybridized to nanocarriers for real-time monitoring of drug release both in vitro and in vivo. This review also provides some recommendations for more in-depth research in future. © 2017 American Institute of Chemical Engineers AIChE J, 2017

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基于无机纳米载体和荧光示踪剂的抗癌药物递送系统

近年来，抗癌纳米药物主要用于化学疗法和联合疗法，其中主要的抗癌药物是通过精心设计的纳米药物递送系统（nano-DDS）进行递送的。配备荧光示踪剂的无机纳米载体已成为监控整个药物输送和释放过程的有吸引力的工具。示踪剂的荧光信号可以与药物释放同时观察到，因此，该策略对于评估纳米DDS的治疗效果非常有用。这篇综述简要概述了三种用于药物输送的无机纳米载体，包括介孔二氧化硅，Fe ₃ O ₄和羟基磷灰石。我们主要讨论了它们的制备过程，载药量以及与纳米载体杂交的不同荧光材料（荧光染料，量子点，荧光大分子和稀土金属）的发展，以实时监测体内和体外的药物释放。体内。这篇综述还提供了一些建议，以便将来进行更深入的研究。©2017美国化学工程师学会AIChE J，2017