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Psychiatric Genomics: An Update and an Agenda
American Journal of Psychiatry ( IF 17.7 ) Pub Date : 2017-10-03 , DOI: 10.1176/appi.ajp.2017.17030283
Patrick F. Sullivan 1 , Arpana Agrawal 1 , Cynthia M. Bulik 1 , Ole A. Andreassen 1 , Anders D. Børglum 1 , Gerome Breen 1 , Sven Cichon 1 , Howard J. Edenberg 1 , Stephen V. Faraone 1 , Joel Gelernter 1 , Carol A. Mathews 1 , Caroline M. Nievergelt 1 , Jordan W. Smoller 1 , Michael C. O’Donovan 1 ,
Affiliation  

The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. This global effort is dedicated to rapid progress and open science, and in the past decade it has delivered an increasing flow of new knowledge about the fundamental basis of common psychiatric disorders. The PGC has recently commenced a program of research designed to deliver “actionable” findings—genomic results that 1) reveal fundamental biology, 2) inform clinical practice, and 3) deliver new therapeutic targets. The central idea of the PGC is to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering a phase of accelerated genetic discovery for multiple psychiatric disorders. These findings are likely to elucidate the genetic portions of these truly complex traits, and this knowledge can then be mined for its relevance for improved therapeutics and its impact on psychiatric practice within a precision medicine framework.

[AJP at 175: Remembering Our Past As We Envision Our Future

November 1946: The Genetic Theory of Schizophrenia

Franz Kallmann’s influential twin study of schizophrenia in 691 twin pairs was the largest in the field for nearly four decades. (Am J Psychiatry 1946; 103:309–322)]



中文翻译:

精神病学基因组学:一个更新和一个议程

精神病基因组学协会(PGC)是精神病学史上最大的协会。这项全球性努力致力于快速进步和开放科学,并且在过去的十年中,它提供了有关常见精神病基本原理的新知识。PGC最近启动了一项旨在提供“可行的”发现的研究计划,即1)揭示基本生物学信息,2)指导临床实践以及3)提供新治疗靶点的基因组结果。PGC的中心思想是将家族史危险因素转化为生物学,临床和治疗上有意义的见解。新出现的发现表明我们正在进入加速发现多种精神病的遗传学阶段。

[AJP在175:展望未来时缅怀我们的过去

1946年11月:精神分裂症的遗传学理论

弗朗兹·卡尔曼(Franz Kallmann)在691对双胞胎中对精神分裂症进行了有影响力的双胞胎研究,这是该领域近40年来最大的研究。(Am J Psychiatry 1946; 103:309–322)]

更新日期:2018-01-05
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