Microglia are the macrophages of the brain and play an important role in Alzheimer's disease (AD). In Cell, Ulland et al. (2017) recently reported that mutations in TREM2, a protein implicated in AD, disrupt microglial energy state and function, thus sabotaging the microglia's ability to defend the brain against amyloid plaques.

中文翻译：

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TREM2：在好时机和坏时保持小胶质细胞健康。

小胶质细胞是大脑的巨噬细胞，在阿尔茨海默氏病（AD）中起重要作用。在Cell中，Ulland等。（2017）最近报道，与AD有关的蛋白TREM2的突变破坏了小胶质细胞的能量状态和功能，从而破坏了小胶质细胞防御淀粉样蛋白斑块的能力。