Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad-spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure-activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad-spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer-based antivirals and represent promising candidates for further development as preventive microbicides.

中文翻译：

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针对寨卡病毒，埃博拉病毒，SARS和其他病原性病毒的大分子抗病毒剂。

病毒病原体继续对医疗保健和社会经济系统构成沉重负担。研发抗病毒药物的努力一再落后于病原体的出现，而越来越广泛的认识是，广谱抗病毒剂将在未来的抗病毒工作中产生最大的影响。这项工作进行了合成聚合物作为新型广泛活性剂的选择，并证明了这些聚合物对寨卡病毒，埃博拉病毒，拉萨病毒，lyssa病毒，狂犬病病毒，马尔堡病毒，埃博拉病毒，流感病毒，单纯疱疹病毒和人类免疫缺陷病毒的活性。本文提出的结果就构成细菌的广谱抗病毒药而言，对这些病原体而言具有结构-活性关系，而就构成广谱抗病毒剂的阴离子电荷和疏水性而言，对聚合物而言，它们为聚合物提供了构效关系。