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Variations in serum concentrations of selected organochlorines among delivering women in Argentina. The EMASAR study†
Environmental Science: Processes & Impacts ( IF 5.5 ) Pub Date : 2017-09-29 00:00:00 , DOI: 10.1039/c7em00278e
Solrunn Hansen 1, 2, 3, 4, 5 , Evert Nieboer 6, 7, 8, 9 , Natalia Bravo 10, 11, 12, 13 , Inger Økland 5, 14, 15, 16 , Silvinia Matiocevich 17, 18, 19, 20 , Marisa Viviana Alvarez 20, 21, 22 , Stein Tore Nilsen 5, 15, 16, 23 , Joan O. Grimalt 10, 11, 12, 13 , Jon Øyvind Odland 1, 2, 3, 4, 5
Affiliation  

The EMASAR study is the first study to describe the body burden of OCs in Argentinian women after delivery. In total, 698 maternal serum samples from Salta (n = 498) and Ushuaia (n = 200) were collected in 2011–2012 and analyzed for a total of 7 polychlorinated biphenyls (PCBs) and 12 pesticide-related compounds. Only 11 of the compounds had detection rates above 60% in one or both places. Compared with Ushuaian women, those from Salta exhibited higher lipid-adjusted concentrations of p,p′-DDE, p,p′-DDT, β-HCH, and PCB 118 (p ≤ 0.003), with no differences in concentrations of PCB 153 and 138. After controlling for age, parity and heritage (born in the province or migrated there from other regions of Argentina), concentrations of p,p′-DDE, p,p′-DDT, β-HCH and all PCBs were significantly higher in Salta natives compared with Ushuaia natives or migrants (p ≤ 0.010). No variations between native and migrated Ushuaian women were observed other than for PCB 153 (6.1 versus 8.6 μg kg−1 lipid, p = 0.022). Age was generally associated positively with the body burden of nearly all OCs and parity negatively so, with p,p′-DDD, o,p′-DDT, and o,p′-DDD residues and α-HCH in Ushuaia being the exceptions. The regional differences in OC concentrations are explained by contrasting domestic sources, historical and current uses, industrial emissions, dietary patterns and lifestyle factors, as well as long-range-transport. The relatively high PCB 118/PCB 180 ratio observed for both Argentinian communities likely reflects the use of technical mixtures with congener-specific composition. In a comprehensive comparison with other countries, the Argentinian OC concentrations were mostly in the lower range. It is concluded that a latitude effect equivalent to that operative in the Arctic region seems unlikely.

中文翻译:

阿根廷分娩妇女中某些有机氯的血清浓度变化。EMASAR研究

EMASAR研究是描述阿根廷妇女分娩后OCs身体负担的第一项研究。在2011-2012年期间,总共从萨尔塔(n = 498)和乌斯怀亚(n = 200)收集了698份孕妇血清样品,并分析了总共7种多氯联苯(PCBs)和12种农药相关化合物。一个或两个位置中只有11种化合物的检出率超过60%。与Ushuaian妇女相比,那些从萨尔塔表现出更高的脂质调整浓度pp '-DDE,pp '-DDT,β-HCH,和印刷电路板118(p≤0.003),与PCB 153和138的浓度无显着差异控制了年龄,胎次和遗产(出生在省内或来自阿根廷的其他地区迁移到此),配制后pp '-DDE,pp滴滴涕,β-HCH和所有多氯联苯萨尔塔当地人均显著高于乌斯怀亚当地人或移民(相比p ≤0.010)。观察其它比PCB 153(6.1天然和迁移Ushuaian妇女之间没有变化8.6微克千克-1脂质,p = 0.022)。年龄通常与几乎所有OC的身体负担呈正相关,而与平价则呈负相关,与pp乌斯怀亚的'-DDD,op' -DDT和op' -DDD残基和α-六氯环己烷除外。OC浓度的区域差异是通过对比国内来源,历史和当前用途,工业排放,饮食模式和生活方式因素以及远距离运输来解释的。在阿根廷两个社区中观察到的相对较高的PCB 118 / PCB 180比可能反映了使用具有同类物特定成分的技术混合物。与其他国家进行的全面比较中,阿根廷的OC浓度大多在较低范围内。结论是,与北极地区相同的纬度效应似乎不太可能。
更新日期:2017-09-29
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