Schizophrenia is a severe and complex psychiatric disorder resulting in delusions, hallucinations, and cognitive impairments. Across a variety of paradigms, an elevated threshold for conscious perception has been repeatedly observed in persons with schizophrenia. Remarkably, even subtle measures of subliminal processing appear to be preserved. We argue here that the dissociation between impaired conscious access and intact unconscious processing may be due to a specific disruption of top-down attentional amplification. This proposal is compatible with the neurophysiological disturbances observed in schizophrenia, including dysconnectivity, abnormal neural oscillations, and glutamatergic and cholinergic dysregulation. Therefore, placing impaired conscious access as a central feature of schizophrenia can help researchers develop a coherent and parsimonious pathophysiological framework of the disease.

中文翻译：

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精神分裂症的意识通路中断

精神分裂症是一种严重而复杂的精神疾病，会导致妄想、幻觉和认知障碍。在各种范式中，在精神分裂症患者中反复观察到意识知觉阈值升高。值得注意的是，即使是潜意识处理的微妙措施似乎也被保留了下来。我们在这里认为，受损的意识通路和完整的无意识加工之间的分离可能是由于自上而下的注意力放大的特定中断。该提议与在精神分裂症中观察到的神经生理学障碍相一致，包括连接障碍、异常神经振荡以及谷氨酸能和胆碱能失调。所以，