As we have summarised in this journal,1 germline DNA variation has been long recognised as a key component of the risk to develop to gastric carcinoma, the discovery pace being greatly accelerated by genome-wide association studies.2 More recently, growing evidence is accumulating also on the association between genetic variation and prognosis of patients with gastric cancer.3 4 Furthermore, investigators have demonstrated that alterations of the circadian rhythm can predispose to a variety of illnesses, including different types of malignancies and gastrointestinal diseases.5 6 Putting together these observations, we studied the relationship between circadian genes germline variation and the overall survival of 460 patients with TNM stage I to IV gastric carcinoma. We considered 21 single nucleotide polymorphisms (SNPs) of 14 circadian pathway genes. Genotyping was performed with real-time quantitative PCR using patient peripheral blood samples. Expression quantitative trait locus (eQTL) analysis was employed to …

中文翻译：

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昼夜节律通路基因的种系变异与胃癌患者的预后

我们考虑了 14 个昼夜节律通路基因的 21 个单核苷酸多态性 (SNP)。使用患者外周血样本通过实时定量 PCR 进行基因分型。表达数量性状基因座 (eQTL) 分析用于……