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Clinical translation of stem cell based interventions for spinal cord injury — Are we there yet?
Advanced Drug Delivery Reviews ( IF 16.1 ) Pub Date : 2017-09-28 , DOI: 10.1016/j.addr.2017.09.021
Harvinder S. Chhabra , Kanchan Sarda

Recent advances in basic science in research related to spinal cord injury (SCI) and regeneration have led to a variety of novel experimental therapeutics designed to promote functionally effective axonal regrowth and sprouting. Stem cell and other cellular interventions have gained lot of attention due to their immense potential of regeneration. These interventions have been tested for their efficacy in case of SCI both at the pre-clinical and clinical level. In this review we critically discuss the published literature on the cellular interventions for SCI and their clinical applications with respect to the strength of evidence established by these studies. The need to curb unethical practice of offering unproven stem cell “therapies” for SCI at a global level is also discussed.



中文翻译:

基于干细胞的脊髓损伤干预措施的临床翻译-我们到了吗?

与脊髓损伤(SCI)和再生有关的基础科学研究的最新进展已导致设计出多种新颖的实验疗法,旨在促进功能有效的轴突再生和发芽。干细胞和其他细胞干预由于其巨大的再生潜力而受到了广泛的关注。已在临床前和临床水平对这些干预措施在SCI情况下的功效进行了测试。在这篇综述中,我们就这些研究建立的证据强度严格讨论了有关SCI的细胞干预及其临床应用的已发表文献。还讨论了遏制在全球范围内为SCI提供未经证实的干细胞“疗法”的不道德做法的必要性。

更新日期:2017-09-28
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