This paper reports the availability of a new Resource with RNA-seq, DNA methylation and H3K9Ac QTL results from 411 brain samples. Many xQTL SNPs influence multiple molecular features, and the authors observe epigenetic mediation of eQTLs in some cases. Reanalyzing GWAS with an xQTL-weighted approach detected 20 new CNS disease susceptibility loci.

中文翻译：

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xQTL图整合了人脑转录组和表观基因组的遗传结构

本文报告了从411个脑样本中获得的具有RNA-seq，DNA甲基化和H3K9Ac QTL结果的新资源的可用性。许多xQTL SNP影响多种分子特征，作者观察到eQTL的表观遗传介导。用xQTL加权方法重新分析GWAS，检测到20个新的CNS疾病易感性基因座。