The complementary nature of positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging makes the development of innovative multimodal PET/NIRF probes a very exciting prospect. Herein, the bioinspired design of novel platform exploiting the strength and specificity of interactions between radioactive and fluorescent biotin derivatives and an avidin core is reported. The combination of an original [¹⁸F]fluoropyridinylated-biotin derivative and commercially available fluorescent biotin derivatives (Atto-425 and Atto-680) is investigated. The in vivo distribution of such a customized platform is also reported, for the first time, in healthy rodent using PET and ex vivo fluorescence imaging.

中文翻译：

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抗生物素蛋白/生物素仿生平台双体内 ¹⁸ F-PET / NIRF分子成像

正电子发射断层扫描（PET）和近红外荧光（NIRF）成像的互补性质使创新的多峰PET / NIRF探针的开发具有令人兴奋的前景。在本文中，报道了利用放射性和荧光生物素衍生物与抗生物素蛋白核心之间相互作用的强度和特异性的新型平台的生物启发设计。研究了原始的[ ¹⁸ F]氟吡啶基化生物素衍生物和市售的荧光生物素衍生物（Atto-425和Atto-680）的组合。在体内，例如定制的平台的分布也有报道，对于第一次，在啮齿动物健康使用PET和离体荧光成像。