A bisfuran dibromide has been established as the versatile and common intermediate for the high-yield synthesis of the three important classes of bisfuran monomers for furan-based renewable materials, bisfuran diacids, diols and diamines. The general synthetic route involves coupling reaction of 2-methylfuran with a ketone (acetone or cyclohexanone) under acidic conditions and bromination reaction of the resulting bisfuran dimethyl compound to produce the bisfuran dibromide intermediate. This dibromide intermediate is subsequently converted to the corresponding bisfuran diacid (via oxidation reaction with KMnO4 under basic conditions), bisfuran diol (by hydrolysis reaction under mild basic conditions), and bisfuran diamine (through the Gabriel reaction). The versatility of the bisfuran dibromide intermediate and the effective transformation into the monomers with high to quantitative yield typically without the need for further purification highlight the two attractive features and potential for large-scale production.

中文翻译：

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通过常用的双呋喃二溴化物中间体简化用于生物资源材料的生物单体的合成：双呋喃二酸，二元醇和二胺

已经建立了双呋喃二溴化物，作为用于呋喃基可再生材料的三类重要的双呋喃单体，双呋喃二酸，二醇和二胺的高产率合成的通用通用中间体。一般的合成路线包括在酸性条件下2-甲基呋喃与酮（丙酮或环己酮）的偶合反应和所得的双呋喃二甲基化合物的溴化反应以生产双呋喃二溴化物中间体。随后将该二溴化物中间体转化为相应的双呋喃二酸（通过在碱性条件下与KMnO4的氧化反应），双呋喃二醇（在温和的碱性条件下通过水解反应）和双呋喃二胺（通过Gabriel反应）。