Fluorescent polymeric nanoparticles (FPNs) as novel theranostic agents for cancer diagnosis and treatment have been widely investigated in recent years. However, most FPNs were constructed with typical inorganic quantum dots, fluorescent proteins, and conventional organic dyes, which have still suffered from many obstacles such as serious cytotoxicity, easy enzymolysis, and vicious aggregation-caused fluorescence quenching (ACQ). Herein, to overcome these problems, we design and synthesize novel FPNs with a unique aggregation-induced emission (AIE) feature using resourceful and cost-effective oxidized sodium alginate (OSA) as natural polymer protected shells of FPNs. Moreover, differing from commercial or synthetic polymers such as PEG, BSA, and lecithin, sodium alginate from marine seaweeds is a cheaper, abundant source and excellent has biocompatibility. Thus-prepared AIE-active OSA-Phe-OSA FPNs by the facile Schiff base condensation have many advantages, such as strong fluorescence, great water dispersity, excellent photostability and desirable biocompatibility, and stained performance. These features endow them great potential for various biomedical applications.

中文翻译：

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多糖对AIE活性荧光聚合物纳米颗粒的新策略：制备和细胞成像。

近年来，已广泛研究了用于癌症诊断和治疗的新型治疗学治疗剂荧光聚合物纳米颗粒（FPN）。但是，大多数FPN都是由典型的无机量子点，荧光蛋白和常规的有机染料构成的，它们仍然遭受许多障碍，例如严重的细胞毒性，易酶解和恶性聚集引起的荧光猝灭（ACQ）。在本文中，为了克服这些问题，我们使用资源丰富且经济高效的氧化海藻酸钠（OSA）作为FPN的天然聚合物保护壳，设计并合成了具有独特聚集诱导发射（AIE）功能的新型FPN。此外，与商用或合成聚合物（例如PEG，BSA和卵磷脂）不同，来自海藻的海藻酸钠价格便宜，来源丰富，优良，具有生物相容性。如此，通过容易的席夫碱缩合制备的AIE-活性OSA-Phe-OSA FPN具有许多优点，例如强荧光，巨大的水分散性，优异的光稳定性和所需的生物相容性以及染色性能。这些功能赋予它们在各种生物医学应用中的巨大潜力。