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Synthesis of Stable Citrate-Capped Silver Nanoprisms
Langmuir ( IF 3.9 ) Pub Date : 2017-09-25 00:00:00 , DOI: 10.1021/acs.langmuir.7b01362
Jason Haber 1, 2 , Konstantin Sokolov 1, 2, 3
Affiliation  

Citrate-stabilized silver nanoprisms (AgNPrs) can be easily functionalized using well-developed thiol based surface chemistry that is an important requirement for biosensor applications utilizing localized surface plasmon resonance (LSPR) and surface-enhanced Raman Scattering (SERS). Unfortunately, currently available protocols for synthesis of citrate-coated AgNPrs do not produce stable nanoparticles thus limiting their usefulness in biosensing applications. Here we address this problem by carrying out a systematic study of citrate-stabilized, peroxide-based synthesis of AgNPrs to optimize reaction conditions for production of stable and reproducible nanoprisms. Our analysis showed that concentration of secondary reducing agent, l-ascorbic acid, is critical to AgNPr stability. Furthermore, we demonstrated that optimization of other synthesis conditions such as stabilizer concentration, rate of silver nitrate addition, and seed dilution result in highly stable nanoprisms with narrow absorbance peaks ranging from 450 nm into near-IR. In addition, the optimized reaction conditions can be used to produce AgNPrs in a one-pot synthesis instead of a previously described two-step reaction. The resulting nanoprisms can readily interact with thiols for easy surface functionalization. These studies provide an optimized set of parameters for precise control of citrate stabilized AgNPr synthesis for biomedical applications.

中文翻译:

稳定的柠檬酸盐封端的银纳米棱镜的合成

柠檬酸盐稳定的银纳米棱镜(AgNPrs)可以使用发达的基于硫醇的表面化学方法轻松实现功能化,这对于利用局部表面等离子体激元共振(LSPR)和表面增强拉曼散射(SERS)的生物传感器应用来说是一项重要要求。不幸的是,目前可用的合成柠檬酸盐包覆的AgNPrs的方案不能产生稳定的纳米颗粒,因此限制了它们在生物传感应用中的实用性。在这里,我们通过对柠檬酸盐稳定的,基于过氧化物的AgNPrs合成进行系统研究,以优化用于稳定和可再现的纳米棱镜生产的反应条件。我们的分析表明,二次还原剂的浓度,l-抗坏血酸,对AgNPr的稳定性至关重要。此外,我们证明优化其他合成条件(例如稳定剂浓度,硝酸银的添加速度和种子稀释度)会导致高度稳定的纳米棱镜,其窄吸收峰的范围从450 nm到近IR。此外,优化的反应条件可用于一锅法合成AgNPrs,而不是先前描述的两步反应。所得的纳米棱镜可以容易地与硫醇相互作用,从而易于表面官能化。这些研究为优化用于生物医学应用的柠檬酸盐稳定的AgNPr合成提供了一组优化的参数。
更新日期:2017-09-25
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