A new method has been developed to determine oxidation products of three chemical warfare agent (CWA) related phenylarsenic compounds from marine biota samples by a liquid chromatography-heated electrospray ionization/tandem mass spectrometry (LC-HESI/MS/MS). The target chemicals were oxidation products of Adamsite (DM[ox]), Clark I (DPA[ox]), and triphenylarsine (TPA[ox]). Method was validated within the concentration range of 1–5, 0.2–5, and 0.2–5 ng/g for DM[ox], DPA[ox], and TPA[ox], respectively. The method was linear, precise and accurate. Limits of quantification (LOQ) were 2.0, 1.3, and 2.1 ng/g for DM[ox], DPA[ox], and TPA[ox], respectively. A total of ten fish samples and one lobster sample collected from near Swedish coast, Måseskär dumpsite were analyzed. Trace concentrations below LOQ values were detected in three samples and the elemental composition of oxidized form of Clark I and/or II was confirmed by LC-HESI/HRMS. To our knowledge, this is the first study that provides the presence of CWA related chemicals in marine biota samples.

中文翻译：

---

LC-HESI / MS / MS检测海洋生物样品中与化学战剂有关的苯砷化合物

通过液相色谱-加热电喷雾电离/串联质谱法（LC-HESI / MS / MS），已开发出一种新方法来确定海洋生物样品中三种化学战剂（CWA）相关的苯基砷化合物的氧化产物。目标化学品是Adamsite（DM [ox]），Clark I（DPA [ox]）和三苯ar（TPA [ox]）的氧化产物。DM [ox]，DPA [ox]和TPA [ox]的浓度范围分别为1–5、0.2–5和0.2–5 ng / g，方法得到了验证。该方法是线性的，精确的和准确的。DM [ox]，DPA [ox]和TPA [ox]的定量限（LOQ）分别为2.0、1.3和2.1 ng / g。分析了从瑞典Måseskär垃圾场附近海岸附近收集的总共10条鱼样品和1条龙虾样品。在三个样品中检测到痕量浓度低于LOQ值，并且通过LC-HESI / HRMS证实了Clark I和/或II的氧化形式的元素组成。据我们所知，这是第一项提供海洋生物样本中与CWA有关的化学物质的研究。