Synthetic polypeptides from the ring-opening polymerization of N-carboxyanhydrides (NCAs) are one of the most important biomaterials. The unique features of these synthetic polypeptides, including their chemical diversity of side chains and their ability to form secondary structures, enable their broad applications in the field of gene delivery, drug delivery, bio-imaging, tissue engineering, and antimicrobials. In this review article, we summarize the recent advances in the design of polypeptide-based supramolecular structures, including complexes with nucleic acids, micelles, vesicles, hybrid nanoparticles, and hydrogels. We also highlight the progress in the chemical design of functional polypeptides, which plays a crucial role to manipulate their assembly behaviours and optimize their biomedical performances. Finally, we conclude the review by discussing the future opportunities in this field, including further studies on the secondary structures and cost-effective synthesis of polypeptide materials.

中文翻译：

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合成多肽：从聚合物设计到超分子组装和生物医学应用

N的开环聚合合成多肽-羧基酐（NCA）是最重要的生物材料之一。这些合成多肽的独特特征，包括其侧链的化学多样性及其形成二级结构的能力，使其在基因传递，药物传递，生物成像，组织工程和抗菌剂等领域具有广泛的应用。在这篇综述文章中，我们总结了基于多肽的超分子结构设计的最新进展，包括与核酸，胶束，囊泡，杂化纳米颗粒和水凝胶的复合物。我们还重点介绍了功能多肽的化学设计进展，该功能在操纵其组装行为和优化其生物医学性能方面起着至关重要的作用。最后，我们通过讨论该领域的未来机会来结束本次回顾，