Hybrid hydrogels based on self-assembling low-molecular-weight gelator (LMWG) DBS-CONHNH₂ (DBS = 1,3;2,4-dibenzylidene-D-sorbitol) and crosslinked polymer gelator (PG) PEGDM (poly(ethyleneglycol) dimethacrylate) are reported, and an active pharmaceutical ingredient (naproxen, NPX) is incorporated. The use of PEGDM as PG enhances the mechanical stiffness of the hybrid gel (G′ increases from 400 to 4500 Pa) – the LMWG enhances its stability to very high frequency. Use of DBS-CONHNH₂ as LMWG enables interactions with NPX and hence allows pH-mediated NPX release – the PG network is largely orthogonal and only interferes to a limited extent. Use of photo-activated PEGDM as PG enables spatially-resolved photo-patterning of robust hybrid gel domains within a preformed LMWG network – the presence of the LMWG enhances the spatial resolution. The photo-patterned multi-domain gel retains pH-mediated NPX release properties and directionally releases NPX into a compartment of higher pH. The two components within these hybrid PG/LMWG hydrogels therefore act largely independently of one another, although they do modify each others properties in subtle ways. Hybrid hydrogels capable of spatially controlled unidirectional release have potential applications in tissue engineering and drug-delivery.

中文翻译：

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空间分辨软质材料，可控释–混合型水凝胶，结合了强大的光活化聚合物凝胶和交互式超分子凝胶

基于自组装低分子量胶凝剂（LMWG）DBS-CONHNH ₂（DBS = 1,3; 2,4-二亚苄基-D-山梨糖醇）和交联聚合物胶凝剂（PG）PEGDM（聚乙二醇）的杂化水凝胶报道了二甲基丙烯酸酯），并掺入了活性药物成分（萘普生，NPX）。PEGDM作为PG的使用可增强杂化凝胶的机械刚度（G '从400 Pa增加至4500 Pa）– LMWG将其稳定性提高至非常高的频率。使用DBS-CONHNH ₂因为LMWG可以与NPX相互作用，因此可以通过pH介导的NPX释放-PG网络在很大程度上是正交的，并且仅在有限的程度上产生干扰。使用光活化的PEGDM作为PG，可以在预制的LMWG网络内对坚固的杂化凝胶域进行空间分辨的光图案化-LMWG的存在增强了空间分辨率。光图案化的多域凝胶保留了pH介导的NPX释放特性，并将NPX定向释放到较高pH的隔室中。尽管它们确实以微妙的方式改变了彼此的特性，但是这些杂化PG / LMWG水凝胶中的两种成分在很大程度上彼此独立地起作用。能够空间控制的单向释放的杂化水凝胶在组织工程和药物递送中具有潜在的应用。