Photoredox catalysis has been developed to achieve oxidative C–H chlorination of aromatic compounds using NaCl as the chlorine source and Na₂S₂O₈ as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp²)–H bonds over C(sp³)–H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug.

中文翻译：

---

室温C（sp ²）–H通过光氧化还原催化氧化氯化

已开发出光氧化还原催化以使用NaCl作为氯源和Na ₂ S ₂ O ₈作为氧化剂实现芳族化合物的CH-H氧化氯化。该反应在室温下发生，对C（sp ²）–H键的选择性高于C（sp ³）–H键的选择性。该方法已用于多种底物的氯化，包括加速合成生物活性化合物和药物的关键中间体。