Metal catalyzed allylic substitution is a cornerstone of organometallic and synthetic chemistry. Enantioselective versions have been developed with catalysts derived from transition metals, most notably molybdenum, nickel, ruthenium, rhodium, iridium, palladium, and copper. The palladium- and the iridium-catalyzed versions have turned out to be particularly versatile in organic synthesis because of the very broad scope of the nucleophile and great functional group compatibility. Assets of the iridium-catalyzed reaction are the formation of branched, chiral products from simple monosubstituted allylic substrates, high degrees of regio- and enantioselectivity, and use of modular, readily available chiral ligands. The possibility to use carbon, nitrogen, oxygen, and sulfur compounds as well as fluoride as nucleophiles allows a wide range of chiral building blocks to be prepared.

中文翻译：

---

铱催化的不对称烯丙基取代反应在目标合成中的应用

金属催化的烯丙基取代是有机金属和合成化学的基础。用衍生自过渡金属，最著名的是钼，镍，钌，铑，铱，钯和铜的催化剂开发了对映选择型。由于亲核试剂的范围很广并且官能团的相容性很高，因此钯和铱催化的化合物在有机合成中特别有用。铱催化反应的资产是由简单的单取代烯丙基底物形成支链手性产物，高度的区域选择性和对映选择性以及使用模块化的，易于获得的手性配体。使用碳，氮，氧的可能性，