Integration of two or more drugs into a multiagent delivery system has been considered to have profound impact on both in vitro and in vivo cancer treatment due to their efficient synergistic effect. This study presents a cheap and simple chitosan hydrogel cross-linked with telechelic difunctional poly(ethylene glycol) (DF-PEG-DF) for synthesis of an injectable and self-healing thermosensitive dual-drug-loaded magnetic hydrogel (DDMH), which contains both doxorubicin (DOX) and docetaxel (DTX) for chemotherapy and iron oxide for magnetic hyperthermia induced stimuli responsive drug release. The as-prepared DDMH not only have good biocompatibility but also exhibit unique self-healing, injectable, asynchronous control release properties. Meanwhile, it shows an excellent magnetic field responsive heat-inducing property, which means that DDMH will produce a large amount of heat to control the surrounding temperature under the alternative magnetic field (AMF). A remarkably improved synergistic effect to triple negative breast cancer cell line is obtained by comparing the therapeutic effect of codelivery of DOX and DTX/PLGA nanoparticles (DTX/PLGA NPs) with DOX or DTX/PLGA NPs alone. In vivo results showed that DDMH exhibited significant higher antitumor efficacy of reducing tumor size compared to single drug-loaded hydrogel. Meanwhile, the AMF-trigger control release of drugs in codelivery system has a more efficient antitumor effect of cancer chemotherapy, indicating that DDMH was a promising multiagent codelivery system for synergistic chemotherapy in the cancer treatment field.

中文翻译：

---

注射和自我修复的热敏磁性水凝胶，用于异步控制阿霉素和多西他赛的释放，以治疗三阴性乳腺癌。

由于其有效的协同作用，已将两种或多种药物整合到多剂递送系统中对体内和体外癌症治疗均产生深远影响。这项研究提出了一种便宜且简单的壳聚糖水凝胶，与远螯双官能聚乙二醇（DF-PEG-DF）交联，用于合成可注射且可自我修复的热敏性双重药物负载磁性水凝胶（DDMH），阿霉素（DOX）和多西他赛（DTX）均用于化学疗法，氧化铁用于磁热疗法可诱导刺激性药物释放。所制备的DDMH不仅具有良好的生物相容性，而且还表现出独特的自我修复，可注射，异步控制释放特性。同时，它具有出色的磁场响应热诱导性能，这意味着在交替磁场（AMF）下，DDMH会产生大量热量来控制周围的温度。通过比较DOX和DTX / PLGA纳米粒子（DTX / PLGA NP）与单独的DOX或DTX / PLGA NP的代码传递的治疗效果，可以获得对三阴性乳腺癌细胞系的显着改善的协同作用。体内结果表明，与单药载水凝胶相比，DDMH在降低肿瘤大小方面显示出显着更高的抗肿瘤功效。同时，代码传递系统中的AMF触发控释药物对癌症化疗具有更有效的抗肿瘤作用，这表明DDMH是在癌症治疗领域中协同化疗的有前途的多药代码传递系统。