In this study, we have developed a series of novel gallium oxide doped bioactive glasses to specifically target osteosarcoma cells while aiding new bone formation. The results show that osteosarcoma (Saos-2) cell death is induced through the addition of gallium oxide. Relative to the gallium-free control glass (0% Ga) glasses containing 1, 2, and 3% Ga decreased Saos-2 cell viability in a dose dependent manner. After 72 h in media preconditioned with 3% Ga Saos-2 cell viability was reduced by over 50%. Corresponding studies undertaken on primary normal human osteoblast cells (NHOst) demonstrated no adverse effects to the gallium containing glasses. Hydroxyapatite formation was observed for all glasses when exposed to simulated body fluid.

中文翻译：

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用于潜在的骨癌应用的掺镓生物活性玻璃的开发与表征

在这项研究中，我们开发了一系列新型的掺杂氧化镓的生物活性玻璃，专门针对骨肉瘤细胞，同时有助于新的骨形成。结果表明，通过加入氧化镓可诱导骨肉瘤（Saos-2）细胞死亡。相对于含有1、2和3％Ga的无镓对照玻璃（0％Ga）玻璃，Saos-2细胞的存活率呈剂量依赖性。在用3％Ga Saos-2预处理的培养基中72小时后，细胞活力降低了50％以上。对原代正常人成骨细胞（NHOst）进行的相应研究表明，对含镓的玻璃没有不利影响。当暴露于模拟体液时，所有玻璃均观察到羟基磷灰石的形成。