A single-flask reaction of silyllithium, α-keto N-tert-butanesulfinyl imidates and aldehydes has been developed for the diastereoselective synthesis of α,β-dihydroxy acid derivatives. In this reaction, the nucleophilic addition of silyllithium to chiral α-keto imidates followed by silyl migration forms chiral aza-enolates, which react diastereoselectively with aldehydes. Subsequent [1,4]-O → O silyl migration affords α-substituted β-(silyoxy)-α-hydroxy imidates.

中文翻译：

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的Silyllithium，α酮反应ñ -叔-Butanesulfinyl亚氨酸酯和醛为α位取代β-（甲硅烷氧基）-α-羟基酸衍生物的不对称合成

的silyllithium，α酮单烧瓶反应ñ -叔-butanesulfinyl亚氨酸酯和醛已为α，β二羟基酸衍生物的非对映选择性合成的发展。在该反应中，甲硅烷基锂亲核加成到手性α-酮酰亚胺上，然后甲硅烷基迁移形成手性氮杂-烯醇盐，它们与醛非对映选择性地反应。随后的[1,4] -O→O甲硅烷基迁移得到α-取代的β-（甲硅烷氧基）-α-羟基酰亚胺。