The surface topology of nano/micro particles play a significant role in modulating their interactions with cells, and may serve as a robust strategy for promoting cellular delivery. However, it is still an on-going challenge for the enhanced cellular delivery by surface-engineered organic-based particles. Herein, a novel kind of porphyrin micro-nano composite particles (MP-NPs), with poly(allylamine hydrochloride)-g-porphyrin MPs (PAH-g-Por MPs) as the core and porphyrin NPs as the protrudent structure on the surface, was prepared through a pH-responsive partial decomposition-induced self-assembly method. The porphyrin domains were less aggregated and easily exposed to cells, leading to significantly enhanced cellular uptake, stronger generation of intracellular reactive oxygen species (ROS), and more effective photodynamic therapy effect compared with their smooth counterpart microparticles (MPs). The novel concept of turning therapeutics into biomimetic nanomaterials for enhanced cellular delivery and therapy may provide an inspiring horizon for the design of photosensitizer or other therapeutic delivery systems.

中文翻译：

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具有表面突出的卟啉纳米颗粒的自组装复合微粒可增强细胞摄取和光动力疗法

纳米/微粒的表面拓扑结构在调节其与细胞的相互作用中起着重要作用，并且可以作为促进细胞递送的可靠策略。然而，通过表面工程有机基颗粒增强细胞递送仍然是一个持续的挑战。本文以聚（烯丙胺盐酸盐）-g-卟啉MPs（PAH-g-Por MPs）为核心，以卟啉NPs为突出结构的新型卟啉微纳米复合颗粒（MP-NPs）为研究对象。通过pH响应的部分分解诱导的自组装方法制备。卟啉结构域聚集较少，容易暴露于细胞，导致细胞摄取显着增强，细胞内活性氧（ROS）生成更强，与其光滑的对应微粒（MPs）相比，具有更有效的光动力疗法效果。将治疗剂转变为仿生纳米材料以增强细胞递送和治疗的新颖概念可以为光敏剂或其他治疗剂递送系统的设计提供启发。