Effect of N- and C-terminal functional groups on the stability of collagen triple helices,Chemical Communications

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Effect of N- and C-terminal functional groups on the stability of collagen triple helices
Chemical Communications ( IF 4.9 ) Pub Date : 2017-09-22 00:00:00 , DOI: 10.1039/c7cc05837c
Jasmine Egli _{1,

2,

3,

4,

5} , Roman S. Erdmann _{1,

2,

3,

4,

5} , Pascal J. Schmidt _{1,

2,

3,

4,

5} , Helma Wennemers _{1,

2,

3,

4,

5}

Affiliation

The effect of charged versus neutral N- and C-termini on the stability of the collagen triple helix was examined. Thermal denaturation studies at different pH with collagen model peptides showed that an ammonium group at the N-terminus destabilizes the triple helix more than a carboxylate at the C-terminus. A neutral carboxylic acid stabilizes the triple helix more than an amido moiety at the C-terminus.

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