RNAs of the protein synthesis machinery relocalize to enhance the response to nutrients The digestive tract has to cope with the challenge of functioning efficiently despite irregular cycles of eating and fasting. Digestion and absorption of nutrients require large quantities of proteins, mainly enzymes and transporters (1). Although these proteins must be available in the epithelial cells that line the stomach and intestines within minutes upon feeding, their continuous production would impose high upkeep costs on the fasting organism. On page 1299 of this issue, Moor et al. (2) identify a mechanism that may account for the responsiveness of the digestive system: The monolayer of enterocytes (which form the intestinal epithelium) controls protein expression at the level of translation, through regulated RNA localization.

中文翻译：

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RNA 定位促进翻译

蛋白质合成机器的 RNA 重新定位以增强对营养的反应 消化道必须应对有效运作的挑战，尽管饮食和禁食周期不规律。营养物质的消化和吸收需要大量蛋白质，主要是酶和转运蛋白 (1)。尽管这些蛋白质必须在进食后几分钟内在胃和肠内衬的上皮细胞中可用，但它们的持续生产会给禁食生物带来高昂的维护成本。在本期第 1299 页上，Moor 等人。(2) 确定可能解释消化系统反应的机制：单层肠细胞（形成肠上皮）通过调节 RNA 定位在翻译水平控制蛋白质表达。