Inactivation of PERVs in the pig genome increases the safety of xenotransplantation Xenotransplantation, where tissue from one species is transplanted into a different species, is currently under development to help alleviate the increasing shortage of human tissues and organs for transplantation to treat organ failure. For several reasons, which include the size and physiology of the organs, the ease of genetic modification and cloning, and the large number of progeny and short reproduction cycle, pigs are the animals of choice for organ transplant in humans. Three major problems need to be solved before xenotransplantation becomes a clinical reality: immunological rejection, physiological incompatibility, and the risk of transmission of porcine microorganisms that are able to induce a disease (zoonosis) in the human recipient. On page 1303 of this issue, Niu et al. (1) demonstrate how to increase the safety of xenotransplantation.

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猪器官移植研究进展

猪基因组中 PERV 的失活提高了异种移植的安全性 异种移植，即将一个物种的组织移植到不同物种中，目前正在开发中，以帮助缓解用于移植治疗器官衰竭的人体组织和器官日益短缺的问题。出于多种原因，包括器官的大小和生理学、基因改造和克隆的容易性以及后代数量多和繁殖周期短，猪是人类器官移植的首选动物。在异种移植成为临床现实之前需要解决三个主要问题：免疫排斥、生理不相容性以及能够在人类受体中诱发疾病（人畜共患病）的猪微生物传播风险。在本期第 1303 页，Niu 等人。(1) 展示如何提高异种移植的安全性。