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Branched-Selective Intermolecular Ketone α-Alkylation with Unactivated Alkenes via an Enamide Directing Strategy
Journal of the American Chemical Society ( IF 15.0 ) Pub Date : 2017-09-21 00:00:00 , DOI: 10.1021/jacs.7b08581
Dong Xing 1 , Guangbin Dong 1
Affiliation  

We describe a strategy for intermolecular branched-selective α-alkylation of ketones using simple alkenes as the alkylating agents. Enamides derived from isoindolin-1-one provide an excellent directing template for catalytic activation of ketone α-positions. High branched selectivity is obtained for both aliphatic and aromatic alkenes using a cationic iridium catalyst. Preliminary mechanistic study favors an Ir–C migratory insertion pathway.

中文翻译:

通过酰胺定向策略与未活化烯烃的支链选择性分子间酮α-烷基化

我们描述了使用简单烯烃作为烷基化剂的酮的分子间分支选择性α-烷基化的策略。衍生自异吲哚啉-1-酮的酰胺为酮α-位的催化活化提供了极好的指导模板。使用阳离子铱催化剂对脂族和芳族烯烃均获得高支化选择性。初步的机理研究倾向于Ir-C迁移插入途径。
更新日期:2017-09-21
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