The treatment of anal cancer in patients who are seropositive for HIV (HIV-positive) has been controversial for more than 3 decades. Current treatment guidelines recommend that healthy HIV-positive patients receive standard fluorouracil and mitomycin C concurrent chemoradiotherapy, but some investigators question whether these patients experience more severe toxic effects or worse long-term outcomes that might necessitate a modified treatment approach. This study investigates the influence of HIV status on patient outcomes in a national cohort of US veterans.

中文翻译：

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高效抗逆转录病毒疗法时代的艾滋病毒感染状况与肛门鳞状细胞癌预后的关系

HIV阳性（HIV阳性）的患者对肛门癌的治疗已引起争议超过3年。当前的治疗指南建议健康的HIV阳性患者接受标准的氟尿嘧啶和丝裂霉素C同步放化疗，但是一些研究者质疑这些患者是否会经历更严重的毒性作用或更长期的不良后果，可能需要采用改良的治疗方法。这项研究调查了美国退伍军人队列中艾滋病毒感染状况对患者预后的影响。