A practical, one-pot procedure for the synthesis of privileged 1,2,3,4-tetrahydroisoquinolines on a multi-gram scale takes place under base-free conditions at room temperature, and tolerates a wide range of functionalities The reaction is highly chemoselective, and pure products are obtained by simple filtration. A complementary two-step procedure gives the Mannich products in good yields.

中文翻译：

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C（sp3）–H键的无金属活化和特权快速的1-取代的1,2,3,4-四氢异喹啉的实用快速合成

在室温下在无碱条件下进行实用的一锅法合成几克规模的1,2,3,4-四氢异喹啉的特权方法，该方法具有宽泛的化学选择性。 ，通过简单的过滤即可获得纯净的产品。互补的两步操作可以使曼尼希产品具有良好的产量。