To the editor: Germ line–activating mutations of protein tyrosine phosphatase PTPN11 (Shp2), a positive regulator of the Ras signaling pathway,[1][1] account for more than 50% of patients with Noonan syndrome.[2][2] These patients have an increased risk of developing leukemias,[3][3] especially

中文翻译：

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CCL3是干细胞微环境中Ptpn11激活突变的致白血病作用的关键介质

致编辑：蛋白质酪氨酸磷酸酶PTPN11（Shp2）的胚系激活突变，Ras信号通路的正调节因子，[1][1]占Noonan综合征患者的50%以上。[2][2] ] 这些患者患白血病的风险增加，[3][3] 尤其是