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Cofactor engineering for more efficient production of chemicals and biofuels
Biotechnology Advances ( IF 16.0 ) Pub Date : 2017-09-20 , DOI: 10.1016/j.biotechadv.2017.09.008
Meng Wang , Biqiang Chen , Yunming Fang , Tianwei Tan

Cofactors are involved in numerous intracellular reactions and critically influence redox balance and cellular metabolism. Cofactor engineering can support and promote the biocatalysis process, even help driving thermodynamically unfavorable reactions forwards. To achieve efficient production of chemicals and biofuels, cofactor engineering strategies such as altering cofactor supply or modifying reactants' cofactor preference have been developed to maintain redox balance. This review focuses primarily on the effects of cofactor engineering on carbon and energy metabolism. Coupling carbon metabolism with cofactor engineering can promote large-scale production, and even offer possibilities for producing new products or converting new materials.



中文翻译:

辅助因子工程,可更高效地生产化学物质和生物燃料

辅助因子参与许多细胞内反应,并严重影响氧化还原平衡和细胞代谢。辅助因子工程可以支持和促进生物催化过程,甚至有助于推动热力学不利的反应向前发展。为了实现化学药品和生物燃料的高效生产,已开发了辅助因子工程设计策略,例如改变辅助因子供应或修改反应物的辅助因子偏好,以维持氧化还原平衡。这项审查主要侧重于辅因子工程对碳和能量代谢的影响。碳代谢与辅助因子工程的耦合可以促进大规模生产,甚至为生产新产品或转换新材料提供可能性。

更新日期:2017-09-20
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