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Silver-catalyzed efficient synthesis of enaminones from propargyl alcohols and amines
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2017-09-21 , DOI: 10.1016/j.tetlet.2017.09.054
Mengshun Li , Dongmei Fang , Feng Geng , Xianping Dai

Enaminones are used as the key intermediates to construct heterocyclic compounds with various bioactivities. In this study, a simple and efficient approach for the synthesis of enaminones via amination of propargyl alcohols was developed. Under the catalysis of Ag2CO3, the reaction proceeded smoothly to afford the desired products in good yields. Preliminary mechanism experiments showed that Ag2CO3 played an essential role in the procedure of the reaction.



中文翻译:

银从炔丙基醇和胺催化高效合成烯胺酮

烯胺酮用作构建具有各种生物活性的杂环化合物的关键中间体。在这项研究中,开发了一种通过炔丙醇胺化合成烯胺酮的简单有效的方法。在Ag 2 CO 3的催化下,反应顺利进行,以高收率得到所需产物。初步的机理实验表明,Ag 2 CO 3在反应过程中起着至关重要的作用。

更新日期:2017-09-21
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