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Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
Nature Reviews Molecular Cell Biology ( IF 112.7 ) Pub Date : 2017-08-09 00:00:00 , DOI: 10.1038/nrm.2017.68
Nard Kubben , Tom Misteli

Ageing is the predominant risk factor for many common diseases. Human premature ageing diseases are powerful model systems to identify and characterize cellular mechanisms that underpin physiological ageing. Their study also leads to a better understanding of the causes, drivers and potential therapeutic strategies of common diseases associated with ageing, including neurological disorders, diabetes, cardiovascular diseases and cancer. Using the rare premature ageing disorder Hutchinson–Gilford progeria syndrome as a paradigm, we discuss here the shared mechanisms between premature ageing and ageing-associated diseases, including defects in genetic, epigenetic and metabolic pathways; mitochondrial and protein homeostasis; cell cycle; and stem cell-regenerative capacity.

中文翻译:

早衰和衰老相关疾病的分子和细胞共享机制

衰老是许多常见疾病的主要危险因素。人类早衰疾病是强大的模型系统,可以识别和表征支持生理衰老的细胞机制。他们的研究还使人们对与衰老相关的常见疾病(包括神经系统疾病,糖尿病,心血管疾病和癌症)的病因,驱动因素和潜在的治疗策略有了更好的了解。以罕见的过早衰老Hutchinson-Gilford早衰综合症为范例,我们在这里讨论过早衰老与衰老相关疾病之间的共享机制,包括遗传,表观遗传和代谢途径的缺陷。线粒体和蛋白质体内平衡;细胞周期; 和干细胞的再生能力。
更新日期:2017-09-21
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