Like smoking a rabbit out of a hole, researchers are testing the ability of an experimental cancer drug to reactivate latent HIV and expose it to antiretroviral treatment. The drug, called JQ1, targets the short form of a viral protein called BRD4, which is involved in virus transcription. JQ1 seems to remove the protein, allowing the transcription machinery to come back into action. Once HIV is transcribed and translated, it can be eliminated with standard antiretroviral therapy. This strategy could be a useful method in the stubborn last yard to effectively eradicate the virus from a patient's body.

中文翻译：

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研究简报

就像从洞里抽兔子一样，研究人员正在测试一种实验性癌症药物重新激活潜伏性HIV并将其暴露于抗逆转录病毒治疗的能力。这种名为JQ1的药物针对的是一种称为BRD4的病毒蛋白的短形式，该蛋白与病毒转录有关。JQ1似乎去除了蛋白质，使转录机制重新起作用。转录并翻译了HIV后，可以使用标准的抗逆转录病毒疗法将其消除。在顽固的后院，此策略可能是一种有用的方法，可以有效地从患者体内清除病毒。