We wished to improve the unsatisfactory adsorption and elution efficiencies in conventional magnetic molecular imprinting technology. In this work, a reliable strategy to prepare magnetic molecularly imprinted nanoparticles (MMINs) with rapid rebinding and elution speed was introduced. To decrease the mass-transfer retention of the templates, glycoprotein immunoglobulin (Ig)G was pre-immobilized to form homogeneous and monostratified three-dimensionally imprinted cavities on the surface of magnetic carriers. To shorten the transfer route of the templates, the polymerizaiton process was controlled precisely to form well-defined molecularly imprinted polymer (MIP) films of thickness 12 nm. In this way, the effectiveness of the mass transfer of the templates was maximized, and the length of the transfer route was minimized. As a result, the prepared MMINs showed improved adsorption and elution efficiencies compared with the conventional magnetic molecularly imprinted polymers (MMIPs), and exhibited great selectivity towards the templates.

中文翻译：

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基于简化的传质工艺，用于选择性提取IgG的改进的表面印迹

我们希望改善常规磁性分子印迹技术中不令人满意的吸附和洗脱效率。在这项工作中，介绍了一种可靠的策略来制备具有快速结合和洗脱速度的磁性分子印迹纳米颗粒（MMIN）。为了减少模板的传质保留，将糖蛋白免疫球蛋白（Ig）G预固定，以在磁性载体表面上形成均匀且单层的三维印迹腔。为了缩短模板的转移途径，精确控制了聚合过程，以形成厚度为12 nm的清晰的分子印迹聚合物（MIP）膜。以此方式，模板的大规模转移的有效性被最大化，并且转移路径的长度被最小化。因此，