A modular total synthesis of mycolactone A/B, the exotoxin produced by Mycobacterium ulcerans, has been achieved through the orchestration of several Pd-catalyzed key steps. While this route leads to a mixture of the natural product and its C12 epimer (4:1 ratio), this was inconsequential from the biological activity standpoint. Compared to the previously reported routes, this synthetic blueprint allows the late-stage modification of the toxin, as exemplified by the preparation of [22,22,22-²H₃]-mycolactone A/B.

中文翻译：

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Mycolactone A / B及其[ ² H]-异聚体的模块式全合成

通过编排几个Pd催化的关键步骤，已实现了霉菌内酯A / B（溃疡分枝杆菌产生的外毒素）的模块化全合成。虽然这种途径导致及其差向异构体C12（4天然产物的混合物：1倍的比率），这是从生物活性观点来看无关紧要的。相较于先前报道的路线，该合成蓝图允许毒素的后期变形例中，由[22,22,22-的制备例举² ħ ₃ ] -mycolactone A / B。