Synthesis of 4-benzylpyridines via Pd-catalyzed CH3-arylation of 4-picoline,Organic & Biomolecular Chemistry

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Synthesis of 4-benzylpyridines via Pd-catalyzed CH3-arylation of 4-picoline
Organic & Biomolecular Chemistry ( IF 3.2 ) Pub Date : 2017-08-24 00:00:00 , DOI: 10.1039/c7ob01726j
Jing Wu _{1,

2,

3,

4,

5} , Dadian Wang _{1,

2,

3,

4,

5} , Xiang Chen _{1,

2,

3,

4,

5} , Qingwen Gui _{1,

2,

3,

4,

5} , Hua Li _{5,

6,

7,

8,

9} , Ze Tan _{1,

2,

3,

4,

5} , Genping Huang _{5,

6,

7,

8,

9} , Guangwei Wang _{5,

6,

7,

8,

9}

Affiliation

A highly efficient synthesis of 4-benzylpyridines was developed via Pd-catalyzed C(sp³)–H arylation between 4-picoline and aryl halides. It was found that the best yields were achieved with a simple Pd(PPh₃)₄ catalyst and Cs₂CO₃ as the base. Compared with the known methods, our reaction does not require the use of a strong organometallic reagent as the base.

中文翻译：

4- benzylpyridines合成通过Pd催化的CH ₃ -arylation 4-甲基吡啶的

通过Pd催化4-甲基吡啶和芳基卤化物之间的C（sp ³）-H芳基化反应，开发了4-苄基吡啶的高效合成方法。发现以简单的Pd（PPh ₃）₄催化剂和Cs ₂ CO ₃为碱可获得最佳产率。与已知方法相比，我们的反应不需要使用强有机金属试剂作为碱。

更新日期：2017-09-20

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